[Clinical and immunological studies on transplantation of total cornea with circular lamellar sclera].

OBJECTIVE: To observe the clinical results of total cornea with circular lamellar sclera transplantation (CST) and study its immunological mechanisms by animal experiments. METHODS: 109 patients with corneal transplantation were retrospectively analyzed, and according to the methods of operation they were divided into groups to compare their rate of rejection and the time of occurrence of corneal neovascularization. The methods of grouping and operation in animal experiments were similar to that in the clinical practice. RESULTS: The time of occurrence of neovascularization and rejection of CST were later than that in the total corneal transplantation (TCT), and the postoperative rate of rejection at 3 to 6 months was obviously increased in comparison with that in the partial penetrating keratoplasty (PKP). CONCLUSION: CST is an important method for rebuilding ocular anterior segment, and the donor limbus is active in the immunological of rejection.