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[OPG, a possible candidate for the treatment of rheumatoid arthritis].

Hisataka Yasuda

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Abstract

Osteoprotegerin (OPG) is an osteoclastogenesis inhibitory factor that we have cloned, and is a decoy receptor that inhibits the binding of an osteoclast differentiation factor, RANKL and its receptor RANK. Pharmacological and developmental approaches have demonstrated that OPG inhibits osteoclastogenesis and bone resorption in vivo. OPG may be useful for and applicable to the treatment of bone destruction in rheumatoid arthritis.

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What this paper is about

Osteoprotegerin (OPG) is an osteoclastogenesis inhibitory factor that we have cloned, and is a decoy receptor that inhibits the binding of an osteoclast differentiation factor, RANKL and its receptor RANK. Pharmacological and developmental approaches have demonstrated that OPG inhibits osteoclastogenesis and bone resorption in vivo. OPG may be useful for and applicable to the treatment of bone destruction in rheumatoid arthritis.

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Method / approach

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Available abstract

Osteoprotegerin (OPG) is an osteoclastogenesis inhibitory factor that we have cloned, and is a decoy receptor that inhibits the binding of an osteoclast differentiation factor, RANKL and its receptor RANK. Pharmacological and developmental approaches have demonstrated that OPG inhibits osteoclastogenesis and bone resorption in vivo. OPG may be useful for and applicable to the treatment of bone destruction in rheumatoid arthritis.

Key concepts: Osteoprotegerin, RANKL, Decoy, Osteoclast, Bone resorption, Rheumatoid arthritis, Receptor, Medicine

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[OPG, a possible candidate for the treatment of rheumatoid arthritis]. — Research Paper | ScholarLens