Autosomal Dominant Ophthalmologic Disorders and Linkage/Discussion of the Paper on Autosomal Dominant Linkage Relationships Associated with Ophthalmological Disorders

A consideration of the currently established autosomal dominant linkage relationships to ophthalmologic disorders was utilized to review the principles of linkage. If cross-over does not occur, as few as 6 informative matings can be utilized to identify probable linkage, and as few as 11 informative matings can be utilized to establish linkage. The potential implications of linkage in diagnosis, prevention, and treatment of heritable disorders was discussed.