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[Pharmacokinetics of nifedipine after a single oral dose in patients with disorders of cerebral circulation].
Sarkissian Ma, S E Akopov, Grigorian Gs, A A Ordukhanian, A G Panosian
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Abstract
The pharmacokinetics of nifedipine was studied in 44 patients with disorders of cerebral circulation. A significant variability of the pharmacokinetic parameters in different patients was revealed. According to the results of the cluster-analysis, the main types (classes) of nifedipine pharmacokinetics were established and the possibility of regarding the patient examined as having this or that type during the measurement of the blood nifedipine concentration 2, 3 and 4 hours after administration of the drug was shown. The relationship between the type of nifedipine pharmacokinetics and its antiaggregatory effect was established.