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[Fibroblast and myofibroblast in the granulation tissue].

Joseph T. Roland

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Abstract

Review of the literature shows that numerous authors admit the existence during various inflammatory reactions, and especially in granulation and cicatricial tissues, of peculiar connective tissue cells e.g. modified fibroblast or myofibroblast, with intermediate features between a fibroblast and a smooth muscle cell. Some of the physical and structural characteristics of these tissues would depend on these cells. The ultrastructural features of the cells in human and experimental pathology as well as their connection with the extracellular matrix are recalled.

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What this paper is about

Review of the literature shows that numerous authors admit the existence during various inflammatory reactions, and especially in granulation and cicatricial tissues, of peculiar connective tissue cells e.g. modified fibroblast or myofibroblast, with intermediate features between a fibroblast and a smooth muscle cell. Some of the physical and structural characteristics of these tissues would depend on these cells. The ultrastructural features of the cells in human and experimental pathology as well as their connection with the extracellular matrix are recalled.

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Available abstract

Review of the literature shows that numerous authors admit the existence during various inflammatory reactions, and especially in granulation and cicatricial tissues, of peculiar connective tissue cells e.g. modified fibroblast or myofibroblast, with intermediate features between a fibroblast and a smooth muscle cell. Some of the physical and structural characteristics of these tissues would depend on these cells. The ultrastructural features of the cells in human and experimental pathology as well as their connection with the extracellular matrix are recalled.

Key concepts: Myofibroblast, Fibroblast, Granulation tissue, Connective tissue, Extracellular matrix, Pathology, Ultrastructure, Cell biology

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