2000•PubMedRequires access

[Lamotrigine in the therapy of resistant epilepsy].

F. De Romanis, N. Sopranzi

Abstract

OBJECTIVE: To evaluate the efficacy of lamotrigine as single agent in patients with refractory epilepsy. MATERIALS AND METHODS: Forty-seven adult patients with refractory epilepsy, in the initial phase received carbamazepine (1208 +/- 82.9 mg/day) plus lamotrigine (561.7 +/- 76.8 mg/day); during the second phase they received lamotrigine alone (206.4 +/- 44.4 mg/day). RESULTS: Lamotrigine monotherapy significantly improved the number of seizures per week in comparison to lamotrigine combined with carbamazepine (p < 0.0001). CONCLUSIONS: Lamotrigine as single agent is more effective than carbamazepine + lamotrigine in patients with refractory epilepsy.

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Key concepts: Lamotrigine, Medicine, Carbamazepine, Epilepsy, Refractory (planetary science), Anticonvulsant, Anesthesia, Psychiatry