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Morphological changes after acetylcholinesterase (AChE) inhibition by dichlorvos (DDVP) in young rabbit brain.

Maria Dambska, Danuta Maślińska

Open publisher page 3 citations

Abstract

The present study is concerned with the lesions of nerve- and glial cells after AChE inhibition during brain development. The investigations were performed on rabbits. Dichlorvos (DDVP) an known inhibitor of AChE was given to young animals per os (4-8 mg/kg of body weight) from 6th to 15th day of life. Cerebral and cerebellar cortex and corpus callosum were examined in electron microscope. Our investigations revealed pathological changes in all neuroectodermal elements. It seems that inhibition of AChE induced by DDVP intoxication led to damage of biologic membranes. This is particularly harmful for differentiating and maturing cells.

About this research paper

What this paper is about

The present study is concerned with the lesions of nerve- and glial cells after AChE inhibition during brain development. The investigations were performed on rabbits. Dichlorvos (DDVP) an known inhibitor of AChE was given to young animals per os (4-8 mg/kg of body weight) from 6th to 15th day of life. Cerebral and cerebellar cortex and corpus callosum were examined in electron microscope. Our investigations revealed pathological changes in all neuroectodermal elements. It seems that inhibition of AChE induced by DDVP intoxication led to damage of biologic membranes. This is particularly harmful for differentiating and maturing cells.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The present study is concerned with the lesions of nerve- and glial cells after AChE inhibition during brain development. The investigations were performed on rabbits. Dichlorvos (DDVP) an known inhibitor of AChE was given to young animals per os (4-8 mg/kg of body weight) from 6th to 15th day of life. Cerebral and cerebellar cortex and corpus callosum were examined in electron microscope. Our investigations revealed pathological changes in all neuroectodermal elements. It seems that inhibition of AChE induced by DDVP intoxication led to damage of biologic membranes. This is particularly harmful for differentiating and maturing cells.

Key concepts: Dichlorvos, Acetylcholinesterase, Aché, Cerebral cortex, Corpus callosum, Cerebellum, Biology, Cerebellar cortex

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Morphological changes after acetylcholinesterase (AChE) inhibition by dichlorvos (DDVP) in young rabbit brain. — Research Paper | ScholarLens