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[TPA increases cell proliferation of HEp-2 cell line in vitro].

Weiwei Liu, Zong-Yuan Zeng, Xibin Xiao

Abstract

OBJECTIVE: To investigate the influence of TPA treatment on HEp-2 cell line in vitro. METHOD: HEp-2 cell line cultured in vitro was treated by different concentration levels of TPA. MTT method was used to detect survival cell ratio of HEp-2. RESULT: Cell growth of HEp-2 after treatment of TPA manifested an peak. The highest peak which was 1.3 to 1.4 times of control cell presented on 10 microg/L concentration level. Cell proliferation ability dropped gradually following increase of TPA concentration. CONCLUSIONS: TPA can increase cell proliferation of HEp-2 cell in vitro.

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Key concepts: In vitro, Cell growth, Cell culture, Cell, Hep G2, Cell counting, Molecular biology, Chemistry