2001•PubMedRequires access
[Expression of cell cycle associated proteins cyclin D1 and P16 in endometrial carcinoma and the correlation between their expression status].
J Xiong, Zhigang Peng, Kun‐Lin Yang
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Abstract
OBJECTIVE: To study the expression of cell cycle associated proteins Cyclin D1, P16 in endometrial carcinoma and their correlation to clinical parameters, and to assess the correlation between their expression status. METHODS: Immunohistochemical method was used to detect Cyclin D1 and P16 expressions in 64 cases of endometrial carcinoma. RESULT: The positive rate of Cyclin D1 was 54.68%. The Cyclin D1 expression was significantly associated with FIGO stage (P < 0.05). The positive rate of P16 was 53.13% and its expression was related to age, histological grade and FIGO stage (P < 0.05). There was an inverse correlation between Cyclin D1 and P16, r = -0.4007 (P < 0.01). CONCLUSION: Cyclin D1 and P16 had cooperative effect and may play an important role in the development and progression of endometrial carcinoma.