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[Relationship between aneuploidy of chromosome 17 and amplification of HER-2/neu gene in the different histological type of breast cancer].

K Kuroso, Yoshihiko Ueda, Yoshiomi Mori

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Abstract

We examined the relationship between the aneuploidy of chromosome 17 and the amplification of HER-2/neu gene by fluorescence in situ hybridization (FISH) in the different histological type of breast cancer (n = 55). 51 patients recognized the aneuploidy that consisted of 37 patients of monosomy and 14 patients of polysomy. In the scirrhous carcinoma, HER-2/neu gene was amplified in 15% of monosomy cases, but it was not amplified in all polysomy cases. In the papillotubular carcinoma, HER-2/neu gene was contrastively amplified in all polysomy cases, but it was not amplified in all monosomy cases. No case of solid-tubular carcinoma recognized the amplification. The relation was different according to the histological type of breast cancer.

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What this paper is about

We examined the relationship between the aneuploidy of chromosome 17 and the amplification of HER-2/neu gene by fluorescence in situ hybridization (FISH) in the different histological type of breast cancer (n = 55). 51 patients recognized the aneuploidy that consisted of 37 patients of monosomy and 14 patients of polysomy. In the scirrhous carcinoma, HER-2/neu gene was amplified in 15% of monosomy cases, but it was not amplified in all polysomy cases. In the papillotubular carcinoma, HER-2/neu gene was contrastively amplified in all polysomy cases, but it was not amplified in all monosomy cases. No case of solid-tubular carcinoma recognized the amplification. The relation was different according to the histological type of breast cancer.

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Available abstract

We examined the relationship between the aneuploidy of chromosome 17 and the amplification of HER-2/neu gene by fluorescence in situ hybridization (FISH) in the different histological type of breast cancer (n = 55). 51 patients recognized the aneuploidy that consisted of 37 patients of monosomy and 14 patients of polysomy. In the scirrhous carcinoma, HER-2/neu gene was amplified in 15% of monosomy cases, but it was not amplified in all polysomy cases. In the papillotubular carcinoma, HER-2/neu gene was contrastively amplified in all polysomy cases, but it was not amplified in all monosomy cases. No case of solid-tubular carcinoma recognized the amplification. The relation was different according to the histological type of breast cancer.

Key concepts: Polysomy, Monosomy, Aneuploidy, Fluorescence in situ hybridization, Biology, Gene duplication, Breast cancer, Chromosome

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[Relationship between aneuploidy of chromosome 17 and amplification of HER-2/neu gene in the different histological type of breast cancer]. — Research Paper | ScholarLens