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[Spontaneous growth of suspended hamster embryonic cells transformed in vitro by methyl-7 benzo(a)anthracene].
Sarah Levy, D. Papadopoulo, Sara Nocentini, Markovits Pm
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Abstract
A transformed and malignant cell line was obtained by treatment of secondary hamster embryo cells with 7-methyl benz(a)anthracene (10 mug/ml of medium). Later on these cells acquired the capacity to grow spontaneously in suspension and form "spheroids". The evolution of this cell line showed similarities between the carcinogenic process in vitro and in vivo.