2008•PubMedRequires access

[Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat].

Simonova Ai, Pozdneev Vf, O A Gomazkov, Medvedeva Na

Abstract

The aim of this study was to investigate how blocking functional endothelin-converting enzyme activity may offer a new approach to inhibition of changes in pulmonary vessels reactivity due to development of hypoxia-induced pulmonary arterial hypertension in rats. This data shows that treatment with endothelin-converting enzyme blocker PP36 significantly reduced pathological changes due to hypoxia-induced pulmonary hypertension. One of the reasons may be the increased production and role of nitric oxide in pulmonary artery tone.

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Available abstract

Key concepts: Hypoxia (environmental), Pulmonary hypertension, Nitric oxide, Endothelin receptor, Endothelin 1, Pulmonary artery, Medicine, Internal medicine