Histological changes in seminiferous epithelium in testis of male mice induced by injection of lipopolysaccharide (LPS).

LPS induces an inflammatory state which kmitates septic shock and which involves also an organ which is immunologically advantageous, namely testicle. Within an area of a gonad, this manifests itself by histological changes in the structure of germinal epithelium. The blockages of cell divisions lead also to disorders in the proportions of cells in particular stages of spermatogenesis, degeneration of germinal epithelium and the decrease of the number of spermatozoa in the lumen of seminiferous tubules. Maximal changes are observed on the 15th day of inflammatory state and they are reversible with the process of the animals' restoration to health. The number of macrophages rises quickly in Leydig's glands and it remains constant till the 28th day after the administration of LPS.