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[Treatment of multi-drug resistant tuberculosis].

Masao Okumura, Shoji Kudoh

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Abstract

Tuberculosis can be cured by 6 months chemotherapy, consisting of isoniazid (INH), rifampicin (RFP), pyrazinamide (PZA), and ethambutol (EB). However, the patients with tuberculosis caused by multi-drug resistant tuberculosis (MDR-TB) bacilli, defined as resistance to at least INH and RFP, poorly respond to this resimen. To work out the strategy for the elimination of MDR-TB, chemotherapy resume must be changed from standard resume to special one, that are made from effective and stronger at least three anti-tuberculosis drugs. The duration of treatment will be 18-24 months usually. If decreasing of tuberculosis bacilli in sputum is failed under new effective resume, surgical treatment may be indicated. Treatment results of MDR-TB are not satisfactory. But we need to not to make new MDR-TB cases.

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What this paper is about

Tuberculosis can be cured by 6 months chemotherapy, consisting of isoniazid (INH), rifampicin (RFP), pyrazinamide (PZA), and ethambutol (EB). However, the patients with tuberculosis caused by multi-drug resistant tuberculosis (MDR-TB) bacilli, defined as resistance to at least INH and RFP, poorly respond to this resimen. To work out the strategy for the elimination of MDR-TB, chemotherapy resume must be changed from standard resume to special one, that are made from effective and stronger at least three anti-tuberculosis drugs. The duration of treatment will be 18-24 months usually. If decreasing of tuberculosis bacilli in sputum is failed under new effective resume, surgical treatment may be indicated. Treatment results of MDR-TB are not satisfactory. But we need to not to make new MDR-TB cases.

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Available abstract

Tuberculosis can be cured by 6 months chemotherapy, consisting of isoniazid (INH), rifampicin (RFP), pyrazinamide (PZA), and ethambutol (EB). However, the patients with tuberculosis caused by multi-drug resistant tuberculosis (MDR-TB) bacilli, defined as resistance to at least INH and RFP, poorly respond to this resimen. To work out the strategy for the elimination of MDR-TB, chemotherapy resume must be changed from standard resume to special one, that are made from effective and stronger at least three anti-tuberculosis drugs. The duration of treatment will be 18-24 months usually. If decreasing of tuberculosis bacilli in sputum is failed under new effective resume, surgical treatment may be indicated. Treatment results of MDR-TB are not satisfactory. But we need to not to make new MDR-TB cases.

Key concepts: Pyrazinamide, Ethambutol, Rifampicin, Tuberculosis, Isoniazid, Medicine, Drug resistance, Chemotherapy

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