1999•PubMedOpen access

Changing reactivity of caprine and ovine mononuclear phagocytes throughout part of the life cycle of Oestrus ovis: assessment through spontaneous and inductible NO production.

C. Duranton, Philippe Dorchies, Grand S, C Lesure, Isabelle Paule Oswald

Abstract

The in vitro reactivity of monocyte-derived macrophages (MDM) from Oestrus ovis (O. ovis) artificially infested lambs and kids was determined by measuring their production of nitric oxide (NO) during the course of infestation. In both species, crude antigenic preparations obtained from O. ovis first instar larvae (L1) were found to significantly (P < 0.01) inhibit this NO production, whereas O. ovis second instar (L2) extract stimulated it. Furthermore, this NO production by MDM decreased during infestation and was related to blood eosinophilia. It appears that crude antigenic extract from O. ovis modified the NO activity of macrophages from lambs and kids infested with O. ovis larvae.

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Key concepts: Oestrus ovis, Ovis, Biology, Infestation, Immunology, Andrology, Larva, Veterinary medicine