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[Stimulation and differentiation of lymphocytes after injuries].

Miriam D. Neher, M. S. Reitz, Lemmel Em

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Abstract

In seven patients who underwent major trauma, stimulation of lymphocytes with phytohaemagglutinin, pokeweed mitogen, and concanavalin A was investigated. Furthermore the differentiation of lymphocytes into T- and B-cells was studied. The synthesis rates of DNA (3H-thymidine incorporation) and RNA (3H-uridine incorporation) are qualitatively depressed at different time intervals. The T- and B-cell relation is altered in favor of the B-lymphocytes.

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What this paper is about

In seven patients who underwent major trauma, stimulation of lymphocytes with phytohaemagglutinin, pokeweed mitogen, and concanavalin A was investigated. Furthermore the differentiation of lymphocytes into T- and B-cells was studied. The synthesis rates of DNA (3H-thymidine incorporation) and RNA (3H-uridine incorporation) are qualitatively depressed at different time intervals. The T- and B-cell relation is altered in favor of the B-lymphocytes.

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Available abstract

In seven patients who underwent major trauma, stimulation of lymphocytes with phytohaemagglutinin, pokeweed mitogen, and concanavalin A was investigated. Furthermore the differentiation of lymphocytes into T- and B-cells was studied. The synthesis rates of DNA (3H-thymidine incorporation) and RNA (3H-uridine incorporation) are qualitatively depressed at different time intervals. The T- and B-cell relation is altered in favor of the B-lymphocytes.

Key concepts: Phytohaemagglutinin, Pokeweed mitogen, Concanavalin A, Stimulation, Thymidine, DNA synthesis, Uridine, Molecular biology

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