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Opioid peptides. Partially modified retro-inverso dermorphin analogues. XIII.

Mauro Marastoni, Gianfranco Balboni, Roberto Tomatis, Severo Salvadori, Borea Pa, Licia Uccelli

Abstract

We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) related peptides. The drastic loss of mu-receptor affinity following introduction of retro-inverso peptide bond between Phe1-D-Ala2 in the new peptide analogues, emphasized the importance of this backbone in the dermorphin peptides.

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Available abstract

Key concepts: Dermorphin, Chemistry, Stereochemistry, Peptide, Peptide bond, Opioid peptide, Oligopeptide, Peptide synthesis