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Susceptibility of African isolates of Plasmodium falciparum to artemisinin (qinghaosu).

J. C. Doury, Pascal Ringwald, J Guélain, Jacques Le Bras

Abstract

We studied in vitro susceptibility of 79 African strains of Plasmodium falciparum to artemisinin, chloroquine, quinine, mefloquine and halofantrine and the potential cross-resistance among the drugs. Most strains presented an 50% inhibitory concentration (IC50) of artemisinin below 26 nmol/liter. A positive correlation between IC50S of artemisinin and those of quinine, mefloquine and halofantrine was observed. Cross resistance between artemisinin and other antimalarials may limit its use as a replacement drug.

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Key concepts: Artemisinin, Halofantrine, Mefloquine, Plasmodium falciparum, Quinine, Chloroquine, Malaria, Artemether