1982•PubMedRequires access
Mutagenicity of methylglyoxal in coffee.
Hiroshi Kasai, K Kumeno, Ziro Yamaizumi, Susumu Nishimura, Masao Nagao, Yuki Fujita, T. Sugimura, Haruo Nukaya, Toshio Kosuge
Open publisher page 91 citations
Abstract
Major carbonyl compounds from a extract of ground roasted coffee beans were identified as 5-hydroxymethylfurfural, acetol, glyoxal, methylglyoxal and diacetyl. Among these carbonyl compounds, methylglyoxal showed considerable mutagenic activity toward Salmonella typhimurium TA100 without S9 mix (around 100,000 revertants/mg). More than 50% of the total mutagenic activity of coffee can be accounted for by the activity of methylglyoxal.