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[Fluorouracil and high-dose folinic acid in the treatment of advanced colorectal carcinoma].

M. Natali, M D'Aprile, Giuseppe Tonini, M Leggio, Patrizia Vici, Silvia Carpano, Francesco Angelini, A Carassai, Maria A. Lopez

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Abstract

Forty-five consecutive patients with advanced colorectal cancer were treated with 5-fluorouracil and high dose folinic acid. Among 43 evaluable patients there were 7 objective responses for an overall response rate of 16%. Toxicity was generally mild and rapidly reversible. Compared to those reported with 5-fluorouracil alone, these results failed to demonstrate an increase in response rate in the treatment of advanced colorectal cancer with the combination of 5-fluorouracil and folinic acid.

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What this paper is about

Forty-five consecutive patients with advanced colorectal cancer were treated with 5-fluorouracil and high dose folinic acid. Among 43 evaluable patients there were 7 objective responses for an overall response rate of 16%. Toxicity was generally mild and rapidly reversible. Compared to those reported with 5-fluorouracil alone, these results failed to demonstrate an increase in response rate in the treatment of advanced colorectal cancer with the combination of 5-fluorouracil and folinic acid.

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Available abstract

Forty-five consecutive patients with advanced colorectal cancer were treated with 5-fluorouracil and high dose folinic acid. Among 43 evaluable patients there were 7 objective responses for an overall response rate of 16%. Toxicity was generally mild and rapidly reversible. Compared to those reported with 5-fluorouracil alone, these results failed to demonstrate an increase in response rate in the treatment of advanced colorectal cancer with the combination of 5-fluorouracil and folinic acid.

Key concepts: Folinic acid, Fluorouracil, Medicine, Colorectal cancer, Toxicity, Internal medicine, Oncology, Chemotherapy

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[Fluorouracil and high-dose folinic acid in the treatment of advanced colorectal carcinoma]. — Research Paper | ScholarLens