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[Effect of dexamethasone on DNA synthesis in macrophages stimulated in vitro by an inflammatory exudate].

J Fontagné, M. Loizeau, D Blondelon, M Adolphe, P Lechat

Abstract

Rat macrophages in culture are induced to synthesize DNA when incubated with Dextran pleural exudate. Previous or simultaneous in vitro treatment with dexamethasone phosphate used at different concentrations was able to inhibit or decrease that induction. This effect could represent a new aspect of the influence of corticosteroids in the inflammatory process.

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Key concepts: Exudate, Dexamethasone, In vitro, DNA synthesis, Chemistry, DNA, Dextran, Pharmacology