[miRNA and its research advance in occupational medicine].
Feifei Hu, Qianqian Zhou, Baoli Zhu
Abstract
Feifei Hu, Qianqian Zhou, Baoli Zhu
Abstract
miRNA是内源性非编码小RNA家族成员之一,长度约为22个核苷酸,广泛存在于植物、动物体[1].它通过与靶基因的结合来抑制mRNA的翻译或诱导其降解从而调节靶基因的表达[2],在细胞的增殖、分化、凋亡、个体的生长发育以及疾病的发生和发展中发挥着重要作用.以往miRNA的研究主要集中于肿瘤领域,近年来miRNA在职业医学领域的应用和研究日益增多。
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miRNA是内源性非编码小RNA家族成员之一,长度约为22个核苷酸,广泛存在于植物、动物体[1].它通过与靶基因的结合来抑制mRNA的翻译或诱导其降解从而调节靶基因的表达[2],在细胞的增殖、分化、凋亡、个体的生长发育以及疾病的发生和发展中发挥着重要作用.以往miRNA的研究主要集中于肿瘤领域,近年来miRNA在职业医学领域的应用和研究日益增多。
Key concepts: Occupational medicine, microRNA, Computational biology, Occupational exposure, Medicine, Environmental health, Biology, Genetics