Chlorpromazine, clotiapine and thioridazine--a comparative clinical trial on Bantu psychotic patients.

In a non-blind assessment of 3 neuroleptic drugs, chlorpromazine (Largactil), thioridazine (Melleril) and clotiapine (Etomine), we found Etomine to be the drug of choice when the diagnosis is in doubt between a toxic psychosis or schizophrenia. This drug also offered the highest discharge rate, 77'7% at 12 weeks compared with 73'5% in the thioridazine group, and 55'5% in the chlorpromazine group. No clouding of consciousness was seen in the clotiapine group, whereas it was troublesome in the chlorpromazine group in patients having received high parenteral doses.