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Effect of cytostatics on some platelet functions in vitro. VI. Vinblastine.

M Parízek, Peter Kubisz

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Abstract

The influence of vinblastine upon principal functions of blood platelets in vitro (adhesion, aggregation, platelet release reaction, membrane stabilization) has been followed using an extended system of laboratory examinations. The authors have found that the concentration of vinblastine which is higher than the average therapeutic dose (10(-5)M) inhibits the functional ability of platelets so that it may cause a thrombopatic disorder.

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What this paper is about

The influence of vinblastine upon principal functions of blood platelets in vitro (adhesion, aggregation, platelet release reaction, membrane stabilization) has been followed using an extended system of laboratory examinations. The authors have found that the concentration of vinblastine which is higher than the average therapeutic dose (10(-5)M) inhibits the functional ability of platelets so that it may cause a thrombopatic disorder.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The influence of vinblastine upon principal functions of blood platelets in vitro (adhesion, aggregation, platelet release reaction, membrane stabilization) has been followed using an extended system of laboratory examinations. The authors have found that the concentration of vinblastine which is higher than the average therapeutic dose (10(-5)M) inhibits the functional ability of platelets so that it may cause a thrombopatic disorder.

Key concepts: Vinblastine, Platelet, In vitro, Pharmacology, Platelet adhesion, Chemistry, Adhesion, Biochemistry

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