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Immunoscintigraphy in human squamous lung cancer using monoclonal antibodies.

Anne Mathieu, J. Lumbroso, Jean‐François Bergmann, Daniel Bellet, Caillaud Jm, Pierre Baldeyrou, Strugo Mc, Claude Bohuon, C Parmentier

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Abstract

We describe immunoscintigraphy using a radiolabelled anti-tumor monoclonal antibody 181-23 in 6 patients with squamous lung cancer. Double-label method using simultaneous injections of 131I MAB and 125I control immunoglobulin was performed to evaluate the specificity of MAB localization in the tumor. Immunohistological localization of MAB in resected specimen was obtained by immunoperoxidase technique. All our data are negative but correlated.

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What this paper is about

We describe immunoscintigraphy using a radiolabelled anti-tumor monoclonal antibody 181-23 in 6 patients with squamous lung cancer. Double-label method using simultaneous injections of 131I MAB and 125I control immunoglobulin was performed to evaluate the specificity of MAB localization in the tumor. Immunohistological localization of MAB in resected specimen was obtained by immunoperoxidase technique. All our data are negative but correlated.

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Available abstract

We describe immunoscintigraphy using a radiolabelled anti-tumor monoclonal antibody 181-23 in 6 patients with squamous lung cancer. Double-label method using simultaneous injections of 131I MAB and 125I control immunoglobulin was performed to evaluate the specificity of MAB localization in the tumor. Immunohistological localization of MAB in resected specimen was obtained by immunoperoxidase technique. All our data are negative but correlated.

Key concepts: Immunoscintigraphy, Immunoperoxidase, Monoclonal antibody, Lung cancer, Antibody, Pathology, Cancer, Medicine

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Immunoscintigraphy in human squamous lung cancer using monoclonal antibodies. — Research Paper | ScholarLens