1984•PubMedRequires access
Carcinogenicity in rats of ptaquiloside isolated from bracken.
Iwao Hirono, Shigetoshi Aiso, T Yamaji, H Mori, Kiyoyuki Yamada, Haruki Niwa, Makoto Ojika, Kazumasa Wakamatsu, Hideo Kigoshi, Kenji Niiyama
Open publisher page 54 citations
Abstract
The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.