[The content of prostaglandins A and E in the blood and renal tissues in the early phase of experimental acute renal failure caused by the crush syndrome].

Prostaglandin (PG) A and E content in the blood and renal tissues (cortex and medulla) has been studied in 25 dogs in the early phase of acute renal failure (ARF). It has been found that by the 4th hour of compression PG content increases drastically in the blood and renal cortex and decreases in the renal medulla. Compression relief and ARF progress were accompanied by a drop in PG concentration both in the blood and the renal cortex and medulla. It is concluded that enhanced PGE2 synthesis is a protective reaction preventing the damage of the renal structure and function. The following decrease in PGE2 level is mediated by progressing effect of aggressive factors on the interstitial cells of the renal medulla and the endothelial cells of the cortex vessels--as a basic source of endogenous PG synthesis. The results obtained are experimental proof of PGE2 use in the complex therapy of ARF.