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[Pharmacokinetics of pueraria for intranasal on spray in rabbits].

Yi Lu, Tong Zhang, Tao Jian-sheng, XU Lian-ying

Open publisher page 5 citations

Abstract

OBJECTIVE: To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits. METHODS: The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters. RESULTS: The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h. CONCLUSION: The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.

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What this paper is about

OBJECTIVE: To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits. METHODS: The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters. RESULTS: The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h. CONCLUSION: The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.

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Available abstract

OBJECTIVE: To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits. METHODS: The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters. RESULTS: The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h. CONCLUSION: The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.

Key concepts: Puerarin, Pueraria, Pharmacokinetics, Cmax, Pharmacology, Chemistry, High-performance liquid chromatography, Nasal administration

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