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[Influence of nonachlazin, riboxin and isoptin on the blood coagulation system and the anticoagulant effect of heparin].
L V Shevchenko, Ovchinnikova Lk, S I Zolotukhin
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Abstract
Nonachlazin binds in vitro heparin in blood plasma and aqueous medium. This interaction complies with logarithmic dependence. Isoptin increases in vitro plasma susceptibility to heparin, reduces the period of whole blood coagulation and thrombin time. Riboxin does not produce in vitro any effect on the blood coagulation parameters and heparin susceptibility. Single and chronic adminstration of the drugs exerts no effect on blood coagulation. Prolonged use of riboxin promotes the increased level of endogenous heparin. Both single and chronic administration of the drugs potentiates the anticoagulant action of heparin.