Platelet Monoamine Oxidase and Epinephrine-Induced Platelet Aggregation
Ennio C. Rossi, Gerlinde Louis, Martha Bieber, E. A. Zeller
Abstract
Ennio C. Rossi, Gerlinde Louis, Martha Bieber, E. A. Zeller
Abstract
Platelet MAO activity and the aggregation response to epinephrine, ADP, and collagen were measured in normal subjects. There was a direct correlation between the amount of platelet MAO activity and the per cent aggregation induced by 1 and 2 micrometer epinephrine. There were lesser correlations between platelet MAO and ADP or collagen-induced aggregation. These findings suggest that platelet MAO may play a role in determining the response of human platelets to epinephrine.
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Platelet MAO activity and the aggregation response to epinephrine, ADP, and collagen were measured in normal subjects. There was a direct correlation between the amount of platelet MAO activity and the per cent aggregation induced by 1 and 2 micrometer epinephrine. There were lesser correlations between platelet MAO and ADP or collagen-induced aggregation. These findings suggest that platelet MAO may play a role in determining the response of human platelets to epinephrine.
Key concepts: Epinephrine, Platelet, Monoamine oxidase, Platelet aggregation, Chemistry, Endocrinology, Internal medicine, Adenosine diphosphate