1975•American Journal of Veterinary ResearchRequires access

Comparison of Lymphocyte Stimulation and Tuberculin Skin Reactivity in Mycobacterium bovis-Infected Macaca mulatta

Charles C. Muscoplat, Charles O. Thoen, R. M. McLaughlin, J. R. Thoenig, A. W. Chen, Donald W. Johnson

Abstract

Lymphocyte immunostimulation tests were conducted on Mycobacterium bovis-infected and tuberculin-negative rhesus macaques (Macaca mulatta), using purified protein derivative (PPD) tuberculins prepared from strains of Mycobacterium tuberculosis and Mycobacterium avium. The stimulation of lymphocytes with M tuberculosis PPD was significantly greater for the M bovis-infected macaques than for the noninfected controls (P smaller than 0.05). The response of lymphocytes from M bovis-infected macaques to stimulation with M tuberculosis PPD was greater than the responses to stimulation with M avium PPD (P smaller than 0.01). The results of in vitro lymphocyte stimulation and tuberculin skinreactivity were similar.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 13 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Tuberculin, Mycobacterium bovis, Tuberculin test, Stimulation, Immunology, Lymphocyte activation, Microbiology, Lymphocyte