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[2 phenotypic variants of B-cell lymphocytic leukemia].
A G Merson, Brosh'e Zh, Gipsh Nm, Karminskaia Nm, O Iu Udris
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Abstract
A phenotype of lymphoid cells of peripheral blood in 38 patients with B-cel chronic lymphocytic leukaemia (B-CLL) was determined by means of a set of monoclonal antibodies. In the majority of the cases (32 persons--group I) the cells had an incomplete phenotype (CD 20+, CD 21-, CD 22-, CD 24+, CD 37+). In 6 patients (group II) cells had all the surface markers peculiar to B-CLL cells (phenotype--CD 20+, CD 21+, CD 22+, CD 24+, CD 37+). In 2 out of 6 cases lymphoid cells contained E-receptor (CD 2+). Cells of the patients from group I and II differed also in the level of TUI-receptor. An assumption is advanced about the existence of two phenotypic variants of B-CLL and about a possible association of CD 21 and CD 22 receptors.