Novel 1,3,4‐Oxadiazole Derivatives of Dihydropyrimidinones: Synthesis, Anti‐Inflammatory, Anthelmintic, and Antibacterial Activity Evaluation

The present study depicts synthesis of a series of some novel5‐(5‐(aryl)‐1,3,4‐oxadiazol‐2‐yl)‐3,4‐dihydro‐6‐methyl‐4‐styrylpyrimidin‐2(1H)‐onederivatives. All the newly synthesized compounds were characterized by FTIR,1H NMR,13C NMR, mass spectrometry, and elemental analysis. The compounds were evaluated for theirin vivoanti‐inflammatory activity by the carrageenan‐induced rat paw edema method. The compounds were also screened for their anthelmintic activity on Indian earthworms and antibacterial activity against some gram positive and gram negative strains of bacteria. This pharmacological activity evaluation revealed that, among all the compounds screened, compounds4band4cwere found to have promising anti‐inflammatory activity. Interestingly, compounds4b,4c, and4iexhibited appreciable anthelmintic property, while compounds4c,4g, and4hshowed leading antibacterial activity against the selected pathogenic strains of bacteria.