ScholarLens Back to search
1980•PubMedRequires access

Biosynthesis of thromboxanes.

Sven Hammarström, Ulf Diczfalusy

Open publisher page 10 citations

Abstract

The biosynthesis of thromboxanes from arachidonic acid involves 2 enzymes prostaglandin (PG) endoperoxide synthase (cyclooxygenase) which converts arachidonic acid to PGH2 and thromboxane synthase which isomerizes PGH2 to thromboxane A2. This chapter discusses thromboxane synthase. Topics include: 1) resolution of thromboxane synthesizing enzymes; 2) inhibitors of thromboxane synthase; 3) formation of C-17 acids from PG endoperoxides; 4) structural requirements for thromboxane synthase; and 5) conversion of PGG2.

About this research paper

What this paper is about

The biosynthesis of thromboxanes from arachidonic acid involves 2 enzymes prostaglandin (PG) endoperoxide synthase (cyclooxygenase) which converts arachidonic acid to PGH2 and thromboxane synthase which isomerizes PGH2 to thromboxane A2. This chapter discusses thromboxane synthase. Topics include: 1) resolution of thromboxane synthesizing enzymes; 2) inhibitors of thromboxane synthase; 3) formation of C-17 acids from PG endoperoxides; 4) structural requirements for thromboxane synthase; and 5) conversion of PGG2.

Why it matters

OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The biosynthesis of thromboxanes from arachidonic acid involves 2 enzymes prostaglandin (PG) endoperoxide synthase (cyclooxygenase) which converts arachidonic acid to PGH2 and thromboxane synthase which isomerizes PGH2 to thromboxane A2. This chapter discusses thromboxane synthase. Topics include: 1) resolution of thromboxane synthesizing enzymes; 2) inhibitors of thromboxane synthase; 3) formation of C-17 acids from PG endoperoxides; 4) structural requirements for thromboxane synthase; and 5) conversion of PGG2.

Key concepts: Thromboxanes, Thromboxane-A synthase, Prostaglandin H2, Thromboxane receptor, Thromboxane, Chemistry, Arachidonic acid, ATP synthase

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Biosynthesis of thromboxanes. — Research Paper | ScholarLens