[Invasive bronchopulmonary aspergillosis treated with itraconazole in a patient with acute leukemia].
Sarcía-Ruiz Jc, Carlos Álvarez, Filomena Floristán, Itziar Hernández, José María Hernández, Alvarez Blanco A, José Pontón
Abstract
Sarcía-Ruiz Jc, Carlos Álvarez, Filomena Floristán, Itziar Hernández, José María Hernández, Alvarez Blanco A, José Pontón
Abstract
A case of invasive broncopulmonar aspergillosis caused by Aspergillus terreus successfully treated with itraconazole is reported in a patient undergoing autologous bone marrow transplantation for acute lymphoblastic leukaemia. Although the patient was on prophylaxis with fluconazole and she did not respond to amphotericin B, there was an excellent response to itraconazole which allowed the transplant without any Aspergillus infection during both the transplant and the post-transplant periods. Due to its oral administration, good tolerance and low toxicity, itraconazole is a promising drug for the treatment of invasive broncopulmonar aspergillosis.
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A case of invasive broncopulmonar aspergillosis caused by Aspergillus terreus successfully treated with itraconazole is reported in a patient undergoing autologous bone marrow transplantation for acute lymphoblastic leukaemia. Although the patient was on prophylaxis with fluconazole and she did not respond to amphotericin B, there was an excellent response to itraconazole which allowed the transplant without any Aspergillus infection during both the transplant and the post-transplant periods. Due to its oral administration, good tolerance and low toxicity, itraconazole is a promising drug for the treatment of invasive broncopulmonar aspergillosis.
Key concepts: Itraconazole, Aspergillosis, Medicine, Amphotericin B, Aspergillus terreus, Fluconazole, Aspergillus, Internal medicine