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[Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus].

Weiping Li, Li Wen, Tao Yang

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Abstract

OBJECTIVE: To assess the relationship between plasma homocysteine with chronic complications in type 2 diabetes mellitus. METHOD: Plasma homocysteine levels, blood glucose, and HbA1c were measured in 60 diabetic patients (including 30 with and 30 without complications) and 31 normal subjects. The difference in the occurrence of chronic complications between patients with and without hyperhomocysteinemia was investigated. RESULTS: Plasma homocysteine level was significantly higher in type 2 diabetic patients with chronic complication than in normal control subjects (P<0.01), and patients with chronic complications had higher homocysteine levels than those without chronic complications (P<0.01). CONCLUSION: Hyperhomocysteinemia is related to chronic complication in 2 diabetes mellitus, possibly due to the injury to the vascular endothelium by homocysteine.

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What this paper is about

OBJECTIVE: To assess the relationship between plasma homocysteine with chronic complications in type 2 diabetes mellitus. METHOD: Plasma homocysteine levels, blood glucose, and HbA1c were measured in 60 diabetic patients (including 30 with and 30 without complications) and 31 normal subjects. The difference in the occurrence of chronic complications between patients with and without hyperhomocysteinemia was investigated. RESULTS: Plasma homocysteine level was significantly higher in type 2 diabetic patients with chronic complication than in normal control subjects (P<0.01), and patients with chronic complications had higher homocysteine levels than those without chronic complications (P<0.01). CONCLUSION: Hyperhomocysteinemia is related to chronic complication in 2 diabetes mellitus, possibly due to the injury to the vascular endothelium by homocysteine.

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Available abstract

OBJECTIVE: To assess the relationship between plasma homocysteine with chronic complications in type 2 diabetes mellitus. METHOD: Plasma homocysteine levels, blood glucose, and HbA1c were measured in 60 diabetic patients (including 30 with and 30 without complications) and 31 normal subjects. The difference in the occurrence of chronic complications between patients with and without hyperhomocysteinemia was investigated. RESULTS: Plasma homocysteine level was significantly higher in type 2 diabetic patients with chronic complication than in normal control subjects (P<0.01), and patients with chronic complications had higher homocysteine levels than those without chronic complications (P<0.01). CONCLUSION: Hyperhomocysteinemia is related to chronic complication in 2 diabetes mellitus, possibly due to the injury to the vascular endothelium by homocysteine.

Key concepts: Hyperhomocysteinemia, Medicine, Homocysteine, Plasma homocysteine, Internal medicine, Complication, Diabetes mellitus, Type 2 Diabetes Mellitus

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[Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus]. — Research Paper | ScholarLens