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Protective effect of ischemic preconditioning on liver.

Y Zhang, B Zhang, Rongfang Pan

Open publisher page 7 citations

Abstract

OBJECTIVE: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury. METHODS: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope. RESULTS: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05). CONCLUSIONS: IPC has protective effect on the liver function.

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What this paper is about

OBJECTIVE: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury. METHODS: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope. RESULTS: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05). CONCLUSIONS: IPC has protective effect on the liver function.

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Available abstract

OBJECTIVE: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury. METHODS: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope. RESULTS: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05). CONCLUSIONS: IPC has protective effect on the liver function.

Key concepts: Pentobarbital, Ischemia, Ischemic preconditioning, Chemistry, Reperfusion injury, Liver injury, Pharmacology, Liver function

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