[Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats].

OBJECTIVE: To investigate the effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats. METHODS: Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovarietomized (ovx), ovarietomized supplied with diethyl stilbestrol (E, 20 microg/kg BW) or genistetin (25, 50, 100 mg/kg BW). After the rats had been fed for three months, the bone mineral density and biomechanical properties and histomorphometric parameters of the rats was analysed. RESULTS: The trabecular bone volume and the mean trabecular plate density and bone density of ovariectomized rats were significantly decreased, while the mean trabecular plate space increased compared with sham animals. After three months supplementation to ovariectomized rats, trabecular bone volume and mean trabecular plate density increased. CONCLUSION: Genistein can reduced bone loss on ovariecromized rats.