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Post-irradiation kinetics of the C3H/He mouse mammary carcinoma as regards tumor volume regrowth time and cell loss.

Noritaka Tanaka, C Tanabe, Yuta Okumura, Kosuke Murakami

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Abstract

The reoxygenation kinetics of the third generation C3H/He mouse mammary carcinoma has been studied and related to the time for 50% of irradiated tumors to regrow to the initial volume at irradiation (TRT-50) and to changes in tumor cell numbers. The experimental results suggest the following conclusions: (1) Fluctuations in TRT-50 values after two-dose irradiation under aerobic conditions are due to reoxygenation. (2) Since the TRT-50 after a second irradiation under hypoxic conditions remains independent of intervals between two doses for at least 3 days, repopulation and synchronization of surviving cells between irradiations is minimal. (3) A decreased cell number and/or cell loss from irradiated tumors is an important factor in tumor reoxygenation.

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What this paper is about

The reoxygenation kinetics of the third generation C3H/He mouse mammary carcinoma has been studied and related to the time for 50% of irradiated tumors to regrow to the initial volume at irradiation (TRT-50) and to changes in tumor cell numbers. The experimental results suggest the following conclusions: (1) Fluctuations in TRT-50 values after two-dose irradiation under aerobic conditions are due to reoxygenation. (2) Since the TRT-50 after a second irradiation under hypoxic conditions remains independent of intervals between two doses for at least 3 days, repopulation and synchronization of surviving cells between irradiations is minimal. (3) A decreased cell number and/or cell loss from irradiated tumors is an important factor in tumor reoxygenation.

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Available abstract

The reoxygenation kinetics of the third generation C3H/He mouse mammary carcinoma has been studied and related to the time for 50% of irradiated tumors to regrow to the initial volume at irradiation (TRT-50) and to changes in tumor cell numbers. The experimental results suggest the following conclusions: (1) Fluctuations in TRT-50 values after two-dose irradiation under aerobic conditions are due to reoxygenation. (2) Since the TRT-50 after a second irradiation under hypoxic conditions remains independent of intervals between two doses for at least 3 days, repopulation and synchronization of surviving cells between irradiations is minimal. (3) A decreased cell number and/or cell loss from irradiated tumors is an important factor in tumor reoxygenation.

Key concepts: Irradiation, Mammary carcinoma, Kinetics, Mammary tumor, Repopulation, Cell, Andrology, Cancer research

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Post-irradiation kinetics of the C3H/He mouse mammary carcinoma as regards tumor volume regrowth time and cell loss. — Research Paper | ScholarLens