[Research progress on oxidative stress and apoptosis].
Qilong Chu, Kedi Yang, Aiguo Wang
Abstract
Qilong Chu, Kedi Yang, Aiguo Wang
Abstract
Many research findings revealed that oxidative stress may induce apoptosis. At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis. In this paper, the progress on oxidative stress and apoptosis was reviewed.
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Many research findings revealed that oxidative stress may induce apoptosis. At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis. In this paper, the progress on oxidative stress and apoptosis was reviewed.
Key concepts: Oxidative stress, Apoptosis, Cell biology, Reactive oxygen species, Mitochondrion, DNA damage, Oxidative phosphorylation, Oxidative damage