[Acid secretion and gastrin release following stimulation with intragastric instillation of a peptone solution in healthy probands and patients with duodenal ulcer].

In 19 DU-patients and in 15 control subjects acid secretion tests were performed by continuous aspiration or by intragastric titration. Pentagastrin (6 micrograms/kg subcutaneously) or a 20% peptone solution (intragastric instillation) were used for stimulation. In 10 control subjects pentagastrin stimulated acid secretion was within the normal range, hypersecretion (greater than 32 mmol/h) was found in the other 5. 14 DU-patients showed hypersecretion, 5 had normal acid secretion. In contrast to these findings intragastric peptone stimulation caused a very uniform acid secretion within each group. Based on these results ulcer patients and healthy controls could be discriminated more exactly. Acid secretion and serum gastrin concentration were significantly higher in DU patients than in controls. There was a significant correlation between maximal gastrin concentrations and peak acid output after peptone stimulation.