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Red blood cell membrane lipid peroxidation and chronic haemolysis in haemodialysis patients.

M Taccone-Gallucci, Riccardo Lubrano, Vincenzo Mazzarella, Donatella Bandino, Carlo Meloni, Massimo Morosetti, M. Elli, Omero Giardini, Vittorio Boffo, Carmela Tozzo

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Abstract

Pre dialysis concentrations of malonyldialdehyde (MDA) in the red blood cell membranes and pre and post dialysis percent variation of plasma haemoglobin levels are studied in a group of uraemic patients on maintenance haemodialysis both before and after a therapeutic trial with vitamin E. The findings show a significant correlation between MDA levels and percent variation of plasma haemoglobin during dialysis, thus indicating that reducing the amount of lipid peroxidation can help to reduce intradialytic chronic haemolysis.

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What this paper is about

Pre dialysis concentrations of malonyldialdehyde (MDA) in the red blood cell membranes and pre and post dialysis percent variation of plasma haemoglobin levels are studied in a group of uraemic patients on maintenance haemodialysis both before and after a therapeutic trial with vitamin E. The findings show a significant correlation between MDA levels and percent variation of plasma haemoglobin during dialysis, thus indicating that reducing the amount of lipid peroxidation can help to reduce intradialytic chronic haemolysis.

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Available abstract

Pre dialysis concentrations of malonyldialdehyde (MDA) in the red blood cell membranes and pre and post dialysis percent variation of plasma haemoglobin levels are studied in a group of uraemic patients on maintenance haemodialysis both before and after a therapeutic trial with vitamin E. The findings show a significant correlation between MDA levels and percent variation of plasma haemoglobin during dialysis, thus indicating that reducing the amount of lipid peroxidation can help to reduce intradialytic chronic haemolysis.

Key concepts: Haemolysis, Lipid peroxidation, Dialysis, Red blood cell, Red Cell, Erythrocyte membrane, Medicine, Hemodialysis

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