2014•PubMedRequires access

[Signaling mechanism of neuroprotective effect of ischemic preconditioning of brain].

Leonid N. Maslov

Abstract

Analysis of published data indicates that Ras-protein and kinases PI3K, Akt, MEK1/2, ERK1/2, PKC, CaMKII are involved in the signaling mechanism of ischemic preconditioning. In addition, it is established that cyclooxigenase-2, NO-synthase and mitK(ATP)-channel are involved in delayed preconditioning. Signaling mechanism of early ischemic preconditioning of brain is remained unstudied.

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Key concepts: Ischemic preconditioning, Mechanism (biology), Neuroprotection, Protein kinase B, Neuroscience, PI3K/AKT/mTOR pathway, Kinase, Protein kinase C