2002•PubMedRequires access

[Th effect of D2-dopamine receptor blockade on glutamate release into extracellular space of Nucleus accumbens during food reinforcement].

Saul'skaia Nb, M O Mikhaĭlova

Abstract

In Sprague-Dawley rats in was shown by means of in vivo microdialysis combined with HPLC-EC analysis that the blockade of D2-dopamine receptors of the n. accumbens by raclopride (10 microM) completely prevents a decrease in accumbal extracellular glutamate level induced by food intake.

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Key concepts: Microdialysis, Nucleus accumbens, Raclopride, Dopamine, Extracellular, Dopamine receptor D2, Glutamate receptor, Blockade