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[Hypothesis: immune complex glomerulonephritis and auto-immunity (author's transl)].

Fournié Gj, J Lulé, Gayral-Ta Minh M, Mignon-Conté Ma, Pourrat Jp, Conté Jj

Abstract

Experimental studies on the NZBxNZW mouse lupus disease and on the development of immune complex (IC) glomerulonephritis in mouse infected with Escherichia coli lead us to state the following hypothesis: two types of factors are implicated in the development of immune complex glomerulonephritis: 1) specific factors leading to the production of IC involving antigens from the triggering agents; 2) non specific factors leading to the production of IC involving auto-antigens.

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Available abstract

Key concepts: Glomerulonephritis, Immune system, Immunology, Antigen, Immune complex, Immunity, Immune complex disease, Biology