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Effect of 'Arogyavardhini' against carbon tetrachloride induced hepatic damage in albino rats.

S V Dange, Pralhad Sadashiv Patki, V M Bapat, D S Shrotri

Abstract

'Arogyavardhini'-an indigenous formulation was evaluated for its hepatoprotective activity in rats, using two models of carbon tetrachloride (CCl4) hepatic damage, one simulating vital hepatitis and the other simulating fatty change. The protective effect was assessed from serum aspartate transaminase (AST) and alkaline phosphatase levels and from histopathological changes in liver. The results revealed that 'Arogyavardhini' (5 mg/100g, PO daily) was effective in minimizing the changes in serum levels of AST and alkaline phosphatase induced by CCI. The protective effect was also evident on histopathological examination.

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Key concepts: Carbon tetrachloride, Alkaline phosphatase, Liver damage, CCL4, Alanine transaminase, Chemistry, Transaminase, Toxic hepatitis