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[Antibiotic strategy in bronchial infections. Role of roxithromycin].

Jacques GAILLAT

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Abstract

BRONCHIAL SUPERINFECTIONS: Macrolides are first-line antibiotics for acute bronchitis and infectious complications of chronic bronchitis. PROVEN EFFICACY: Data in the literature on roxithromycin treatment in respiratory tract infections demonstrate to clinical and bacteriological efficacy at high doses comparable with other available antibiotics. ANTIBIOTIC STRATEGY: These results are explained by the bioavailability of roxithromycin, its antibacterial spectrum, and its pharmacokinetic features (high serum peak, high intracellular and extracellular concentrations).

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What this paper is about

BRONCHIAL SUPERINFECTIONS: Macrolides are first-line antibiotics for acute bronchitis and infectious complications of chronic bronchitis. PROVEN EFFICACY: Data in the literature on roxithromycin treatment in respiratory tract infections demonstrate to clinical and bacteriological efficacy at high doses comparable with other available antibiotics. ANTIBIOTIC STRATEGY: These results are explained by the bioavailability of roxithromycin, its antibacterial spectrum, and its pharmacokinetic features (high serum peak, high intracellular and extracellular concentrations).

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Available abstract

BRONCHIAL SUPERINFECTIONS: Macrolides are first-line antibiotics for acute bronchitis and infectious complications of chronic bronchitis. PROVEN EFFICACY: Data in the literature on roxithromycin treatment in respiratory tract infections demonstrate to clinical and bacteriological efficacy at high doses comparable with other available antibiotics. ANTIBIOTIC STRATEGY: These results are explained by the bioavailability of roxithromycin, its antibacterial spectrum, and its pharmacokinetic features (high serum peak, high intracellular and extracellular concentrations).

Key concepts: Roxithromycin, Medicine, Antibiotics, Chronic bronchitis, Bronchitis, Respiratory tract infections, Bioavailability, Pharmacokinetics

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