2010•Lund University Publications (Lund University)Open access

Differential molecular and behavioural response to L-DOPA in mice injected with 6-hydroxydopamine in the striatum or in the medial forebrain bundle

Veronica Francardo, Alessandra Recchia, Mohsin Mohammed, Hans Nissbrandt, M. Angela Cenci

Abstract

Unilateral lesions of nigrostriatal dopamine ( DA) pathways with 6-hydroxydopamine (6-OHDA) can be used to obtain a model of Parkinson's disease in the mouse. In the present study we examine two types of unilateral 6-OHDA lesions in the mouse for their ability to induce stable motor deficits and supersensitive molecular and behavioural response to L-DOPA.

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Available abstract

Key concepts: Medial forebrain bundle, Hydroxydopamine, Striatum, Dopamine, Oxidopamine, Parkinson's disease, Neuroscience, Nigrostriatal pathway