2003•PubMedRequires access

Impact of iron loading on the activity of isoniazid or ethambutol in the treatment of murine tuberculosis.

Nacer Lounis, Caroline Maslo, C. Truffot-Pernot, J Grosset, R. J. Boelaert

Abstract

OBJECTIVE: To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis. DESIGN: Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days. RESULTS: For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited. CONCLUSION: The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.

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Key concepts: Ethambutol, Isoniazid, Medicine, Tuberculosis, Mycobacterium tuberculosis, Pharmacology, Rifampicin, Microbiology