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[The effect of granulocyte-macrophage colony-stimulating factor on hemopoiesis recovery and the survival of irradiated mice].

Rogacheva Sa, Luzanov Vm, Kirillova En, Baranov Ae, Muksinova Kn

Abstract

A human recombinant granulocytic-and-macrophagic colony-stimulating factor (rGM-CSF) administered repeatedly to irradiated (10 Gy) CBA mice increased CFUs and CFU-GM content, the number of bone marrow granulocytes and erythronormoblasts, and spleen and peripheral blood cellularity. The survival rate of exposed (9.7 Gy) mice repeatedly injected with rGM-CSF increased from 25% (control) to 90%.

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Key concepts: Haematopoiesis, Spleen, Granulocyte macrophage colony-stimulating factor, Granulocyte, Bone marrow, Colony-stimulating factor, Peripheral blood, Macrophage